Foot and mouth disease is one of the most important viral infectious diseases of livestock. It is an endemic in some geographical regions of Iran and is one of the important health and economic problems. The aim of this study was to investigate the epidemiological pattern and geographic distribution of foot and mouth disease in Kermanshah province using geographic information system (GIS) over a 12-year period. Report of foot and mouth disease had been collected during 2011-2022.Then, using ArcGIS 10.6 software, the layers of specific province\\\'s divisions and information related to various parameters, including the total number of livestock\\\'s, examined, diseased, casualties and high-risk foci of the disease in the form of a descriptive table, coordinate system database Geographic (GCS) have connected to the map of the added province. Data analysis has been done based on the difference between the points involved in the disease and the degree of involvement. A significant difference has been observed in the population of ruminants between different regions of the province in the west, center and east (P < 0.05). In the cows, the highest prevalence was in the east with 17.9% and the lowest was in the center with 1.6%. In small ruminants, the highest prevalence was in the east with 19.1% and the lowest in the center with 3.8%. The occurrence of foot and mouth disease in the whole population of large and small ruminants showed a significant difference (P < 0.05). The highest was reported in 2014 and the lowest in 2013. The results of this study are useful in helping livestock health policy makers and adopting control methods, so it is necessary to be careful in recording the epidemiological codes of the GIS system and pay more attention to monitoring.

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