Abstract Introduction: Obesity is still a health problem for humanity. Although the favorable role of exercise on weight loss has been reported. But the effect of the type of exercise is still unclear. Present study compared the effects of continuous exercise (CE) and interval exercise (IE) on fibrillin-1 and asprosin in obese male rats. Methods: Forty- eight male rats divided into six groups including 1) obese IE, 2) obese CE, 3) healthy IE, 4) healthy CE, 5) obese control and 6) healthy control. Groups 1- 4 performed exercises for 8 weeks and 72 hours after the last training session the insulin resistance index, fasting glucose, insulin, fibrillin-1 and asprosin measured. Data analysis performed by Two-way analysis of variance and Kruskal-Wallis tests with SPSS software (P≤0.05). Results: There were significant differences in insulin resistance (P=0.001), fibrillin-1 gene expression (P=0.001), fasting glucose (P=0.001), asprosin serum levels (P=0.001), and insulin (P=0.002) levels between obese IE, obese CE, healthy IE, healthy CE, obese control and healthy control groups. Conclusions: Although obesity increased fibrillin-1 and asprosin, but IE and CE decreased fibrillin-1 and asprosin. Thus IE and CE can be used for controlling fibrillin-1 and asprosin levels as well as an intervention method contributing to the reduction of weight and obesity.

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