Title : ( Synthesis of optimized propolis solid lipid nanoparticles with desirable antimicrobial, antioxidant, and anti-cancer properties )
Authors: fatemeh shahab navaei , Ahmad Asoodeh ,
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Abstract
This study aimed to produce stable propolis nanoparticles with a size below 100 nm, suitablefor various applications in industries such as pharmaceuticals, medicine, cosmetics, food, andpackaging. To achieve this, propolis solid lipid nanoparticles (PSLNs) were synthesized using thehot homogenization method, and the optimized nanoparticles were analyzed using Design Expertsoftware. The properties of the synthesized PSLN were characterized using UV–visible spectroscopy,FTIR, XRD, PSA, TEM, and zeta potential analysis. The results indicated that PSLNs with a size rangeof 57 ± 15 nm remained stable in an aqueous medium at pH 7.4. HPLC analysis showed that the activeingredient of phenols and flavonoids in the extract remained stable after the formation of PSLNs.Antioxidant and antibacterial properties of the extract and nanoparticles were also evaluated. Theresults demonstrated that the biological properties of the extract were effectively preserved in PSLNs,Additionally, the PSLN synthesized exhibited remarkable anticancer properties against the A549cell line and with IC 50 of 0.01 mg/ml after 72 h‑treatment. In conclusion, the optimized PSLNs can beutilized as antioxidant and antibacterial additives and have the potential to be used as a drug or drugcarrier for the treatment of lung cancer.
Keywords
, Propolis, Solid Lipid Nanoparticles, Statistical optimization, Antimicrobial, Antioxidant, Anti-cancer, Flavonoids, Phenols
@article{paperid:1096219,
author = {Shahab Navaei, Fatemeh and Asoodeh, Ahmad},
title = {Synthesis of optimized propolis solid lipid nanoparticles with desirable antimicrobial, antioxidant, and anti-cancer properties},
journal = {Scientific Reports},
year = {2023},
volume = {13},
number = {1},
month = {October},
issn = {2045-2322},
keywords = {Propolis; Solid Lipid Nanoparticles; Statistical optimization; Antimicrobial; Antioxidant; Anti-cancer; Flavonoids; Phenols},
}
%0 Journal Article
%T Synthesis of optimized propolis solid lipid nanoparticles with desirable antimicrobial, antioxidant, and anti-cancer properties
%A Shahab Navaei, Fatemeh
%A Asoodeh, Ahmad
%J Scientific Reports
%@ 2045-2322
%D 2023
