The disease is caused by exposure to toxins produced by Clostridium botulinum and other botulinum toxin–producing clostridia in feed or drinking water.Samples from water contaminated by dog carcasses and Intestinal contents of sheeps that showed clinical signs were examined for presence of botulism‟s toxin according to guideline of control disease center. Tests on autopsy samples and intestinal contents indicated the presence of botulinum toxin in affected animals.The active toxin is absorbed in the small intestine by binding to the receptors on the apical surface of gut epithelial cells. It is then released into the general circulation, reaching all peripheral cholinergic nerve endings.In these sites, the toxin binds to specific receptors and is internalized into the cytosol of the nerve terminus, where it blocks the release of acetylcholine, producing the characteristic paralysis.prevent or minimize feed borne botulism are based on, removing the source of contamination, providing safe and highquality feed and water to farm animals, properly storing animal feed, inspecting water sources for dying or dead small animals and birds and sanitary landfill of carcasses is recommended to prevent contamination of water and feed

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