In this project, we have successfully designed a new Cu‐Ni alloys nanoparticles immobilized in magnetic organo-modified clay (MMT-BAC@ Fe3O4@CuNi) nanocatalyst for the first time through a simple method. Clay minerals have prominent, different, and interesting features. Due to their high selectivity, compatibility with the environment, low cost and low toxicity, and high surface area, they are considered very effective catalysts for a wide range of organic reactions [1]. The structure of the synthesized catalyst was confirmed by EDX, XRD, TEM, IR, SEM, and ICP techniques. The Heterogeneous nanocatalyst was used in the synthesis of pyrimidines, as highly active pharmaceutical compounds in mild condition [2]. The salient features of this protocol include short reaction time, good to excellent product yield, biocompatible conditions, reusable catalyst, low catalyst loading, wide substrate scope, solvent-free conditions and easy workup conditions (Scheme). Scheme: Nanoclay as an eco-friendly and reusable catalyst for green synthesis of pyrimidines References [1] Eftekhari far, B.; Nasr‐Esfahani, M. Synthesis, characterization and application of Fe3O4@ SiO2@ CPTMO@ DEA‐SO3H nanoparticles supported on bentonite nanoclay as a magnetic catalyst for the synthesis of 1, 4‐dihydropyrano [2, 3‐c] pyrazoles. Applied Organometallic Chemistry 2020, 34, e5406. [2] Nasab, N. H.; Raza, H.; Hassan, M.; Kloczkowski, A.; Kim, S. J. A facile green synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones using cysteine as a bio-organic catalyst: Potent urease inhibitors, in vitro evaluation, kinetic mechanism, and molecular docking studies. Journal of Molecular Structure 2023, 1286, 135638.

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