Background and Aim : With considering the importance of chronic stress as one of the most important factors in the occurrence and exacerbation of Alzheimer\\\'s disease,in search of the role of stress axes including the sympathetic axis or the hypothalamus-pituitary-adrenal axis in their effects in the exacerbation of Alzheimer\\\'s disease,in this research by imitating the sympathetic axis of stress, the effects of norepinephrine(NE) prescription in the central nervous system on spatial memory and in the sporadic Alzheimer\\\'s model has been investigated. Methods : The present study was conducted experimentally on 49 male Wistar rats. Animals were randomly divided into 7 groups: 1-month-old and 3-month-old control group, 1-month-old and 3-month-old sham group, single-dose streptozotocin (STZ) group (0.5mg/kg) in 3-month-old, NE group for two weeks in 1-month-old (30 μg daily), two-week NE group in 3-month-old (50 μg daily), two-week NE group at 1 month and a single dose of STZ (0.5mg/kg) at 3 months, single dose group of STZ (0.5mg/kg) and then two weeks of NE in 3-month-old. All prescriptions were done intra cerebro ventricular (i.c.v) one week after recovery from surgery and cannulation. In order to evaluate the cognitive changes, especially in the field of learning and spatial memory in pseudo-Alzheimer\\\'s induced by STZ and also to investigate the effects of NE on it, 3 months after the last injection, the Morris water maze method was used. Results : Single dose injection of STZ at 3 months reduces learning and recall (p < 0.05). The group that received NE daily for 2 weeks at 3 months and the group that received NE daily for 2 weeks at 1 month showed a decrease in learning and recall speed (p < 0.05,p < 0.01,p< 0.001). Single dose injection of STZ at 3 months of age followed by daily injection of NE showed that the 461 process of learning and recall is reduced (p < 0.05,p < 0.01). Daily injection of NE at 1 month and single dose injection of STZ at 3 months reduced learning and recall (p < 0.05,p < 0.01,p< 0.001). Conclusion : increasing the level of NE in the central nervous system by i.c.v injection in healthy adult male rats, that imitates the sympathetic branch of stress,brings destructive effects in the process of learning and remembering, and the speed of this process reduces and disrupts spatial memory; It seems that the symptoms of this disorder are similar to the symptoms of cognitive impairment caused by STZ. Perhaps long-term stimulation by NE causes long-term excitotoxicity and chronic neuroinflammation and then cognitive impairment in healthy rats. The increase of norepinephrine level in the central nervous system did not show much strengthening effects in the cognitive impairment of the Alzheimer\\\'s model caused by STZ, maybe in the mice that have the cognitive impairment caused by STZ neuroinflammation,the inflammatory state is in a state of saturation automatically,so that norepinephrine cannot go beyond it and cannot show the strengthening effect in cognitive disorder.

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