Purpose of Review Receptor tyrosine kinases (RTKs) are single-pass transmembrane receptors that play a key role as signal transducers. Abnormality of RTK has been revealed in a wide spectrum of cancers, providing appropriate targeted therapy. Treatment with common RTK inhibitors is associated with the challenge of resistance, which requires the use of other effec- tive therapeutic agents. Phytochemicals can use or be combined with other therapeutic agents to improve cancer combating efficiency. Recent Findings Curcumin and epigallocatechin-3-gallate are attractive natural ingredients usually due to their powerful anti- cancer functionality, wide spectrum of targets and low toxicity. Many studies conducted on cancer cells and animal models demonstrated that the inhibitory effects of curcumin and epigallocatechin-3-gallate on RTKs and their downstream signaling pathways reduced proliferation, angiogenesis and invasion in a variety of cancers. Among the many documented targets of curcumin and epigallocatechin-3-gallate, RTKs and their related ligands are one of the important suppressive targets of them. Summary This review focuses on the molecular mechanisms of curcumin and epigallocatechin-3-gallate targeting epidermal growth factor receptor, vascular endothelial growth factor and insulin receptor and their downstream signaling pathways like the PI3K/Akt/mTOR, Ras/ERK and NF-κB pathways.

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