The non-steroidal anti-inflammatory drugs (NSAIDs) with antipyretic, anti-inflammatory and analgesic characteristics have become one of the most extensively used drugs all over the world. The residues of these pharmaceuticals can penetrate the ecosystem and cause a serious concern because of the environmental and health implication. Hence, the accurate analytical determination of these drugs in different samples is necessary. The sensitive measurement of NSAIDs depends on an effective and efficient extraction process. In recent years, various extraction techniques including solid-phase microextraction and liquid-phase microextraction have been introduced. This review summarizes the development of new solid-phase micro extraction techniques for determination of non-steroidal anti-inflammatory drugs and also compares their merits and demerits.

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