Title : ( Efficient on-water synthesis of novel pyrano[3,2-e][1,2,4]triazolo[1,5-a]pyrimidines via catalyst-free one-pot three-component reaction )
Authors: Fatemeh Hamidi Dastjerdi , Abbas Ali Esmaeili ,
Full TextAbstract
An efficient, catalyst-free and eco-friendly synthesis of novel pyrano[3,2-e][1,2,4]triazolo[1,5-a]pyrimidines via cyclo-condensation of [1,2,4]triazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione, aromatic aldehydes, and malononitrile has been described using ‘‘On-water” concept. The use of water as a clean media, catalyst-free conditions, excellent functional group acceptance, easier product isolation/purification without column chromatography, short reaction times, and good-to-excellent yields are the remarkable privileges of this protocol. Finally, 1H, 13C NMR, IR, mass spectra, and elemental analyses were conducted to determine the products’ structure.
Keywords
, Green chemistry, One-pot reaction, On-water, Catalyst-free, [1, 2, 4]triazolo[1, 5-a]pyrimidine-5, 7(4H, 6H)-dione Pyrano[3, 2-e][1, 2, 4]triazolo[1, 5-a] pyrimidines
@article{paperid:1101937,
author = {Hamidi Dastjerdi, Fatemeh and Esmaeili, Abbas Ali},
title = {Efficient on-water synthesis of novel pyrano[3,2-e][1,2,4]triazolo[1,5-a]pyrimidines via catalyst-free one-pot three-component reaction},
journal = {Tetrahedron},
year = {2025},
volume = {176},
month = {February},
issn = {0040-4020},
keywords = {Green chemistry; One-pot reaction; On-water; Catalyst-free; [1;2;4]triazolo[1;5-a]pyrimidine-5;7(4H;6H)-dione
Pyrano[3;2-e][1;2;4]triazolo[1;5-a]
pyrimidines},
}
%0 Journal Article
%T Efficient on-water synthesis of novel pyrano[3,2-e][1,2,4]triazolo[1,5-a]pyrimidines via catalyst-free one-pot three-component reaction
%A Hamidi Dastjerdi, Fatemeh
%A Esmaeili, Abbas Ali
%J Tetrahedron
%@ 0040-4020
%D 2025
