Title : ( Sandwich-type aptamer-based biosensors for thrombin detection )
Authors: somayeh sahraneshin samani , Elham Sameiyan , Farideh Tabatabaei yazdi , Sayed Ali Mortazavi , Mona Alibolandi , Mohammad Ramezani , Khalil Abnous ,Access to full-text not allowed by authors
Abstract
hrombin, a proteolytic enzyme, plays an essential role in catalyzing many blood clotting reactions. Thrombin can act as a marker for some blood-related diseases, such as leukemia, thrombosis, Alzheimer\\\\\\\\\\\\\\\'s disease and liver disease. Therefore, its diagnosis is of great importance in the fields of biological and medical research. Biosensors containing sandwich-type structures have attracted much consideration owing to their superior features such as reproducible and stable responses with easy improvement in the sensitivity of detection. Sandwich-type platforms can be designed using a pair of receptors that are able to bind to diverse locations of the same target. Herein, we investigate recent advances in the progress and applications of thrombin aptasensors containing a sandwich-type structure, in which two thrombin-binding aptamers (TBAs) identify different parts of the thrombin molecule, leading to the formation of a sandwich structure and ultimately signal detection. We also discuss the pros and cons of these approaches and outline the most logical approach in each section.
Keywords
, Sandwich, type aptamer, biosensors for thrombin detection@article{paperid:1102129,
author = {Sahraneshin Samani, Somayeh and الهام سامعیان and Tabatabaei Yazdi, Farideh and Mortazavi, Sayed Ali and منا علی بلندی and محمد رمضانی and خلیل ابنوس},
title = {Sandwich-type aptamer-based biosensors for thrombin detection},
journal = {Analytical Methods},
year = {2024},
volume = {16},
number = {14},
month = {January},
issn = {1759-9660},
pages = {1985--2001},
numpages = {16},
keywords = {Sandwich-type aptamer-biosensors for
thrombin detection},
}
%0 Journal Article
%T Sandwich-type aptamer-based biosensors for thrombin detection
%A Sahraneshin Samani, Somayeh
%A الهام سامعیان
%A Tabatabaei Yazdi, Farideh
%A Mortazavi, Sayed Ali
%A منا علی بلندی
%A محمد رمضانی
%A خلیل ابنوس
%J Analytical Methods
%@ 1759-9660
%D 2024