Recent studies have highlighted the potential of quinolone hybrids as molecules with promising biological activities. A series of novel thiazolo[3,2-a]pyrimidine-quinolone hybrids derivatives has been synthesized through the three-component reactions of 4-hydroxybenzo[h]quinolin-2(1H)-one, diverse aldehydes, and thiazolo[3,2-a]pyrimidine compound in the presence of a catalytic amount of L-proline under reflux conditions in EtOH. The products’ structure was identified and verified using their 1H NMR, FT-IR, 13C NMR spectra, elemental analysis, and mass spectrometry data. This Multicomponent domino reaction proceeds smoothly and offers several benefits: operational simplicity, short reaction time, no column chromatography, high atom economy, metal-free reaction conditions, and green media, resulting in good to high yields. The potential biological activities of products can be evaluated in future studies.

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