Bone grafts after blood transfusion are second place in organ transplants in the world. In recent years, importance of bone grafts in healing of bone fractures, delay union, mal union is progressively taking attention in clinical fields. The biphasic calcium phosphate (BCP: HA (hydroxyapatite) /TCP (tri-calcium phosphate)) scaffold is one of the commonly used synthetic bone substitutes, the application of which has been investigated both in vitro and in vivo. OsvehOss BCP (Osveh Asia Medical Instrument Co., Iran) is a synthetic, porous, osteoconductive and bioactive bone substitute for filling/or reconstruction of bone defects. In current animal study, we used OsvehOss biphasic scaffolds to treat calvaria defects in rats and evaluate the histological results to investigate the bone regenerative potential of the OsvehOss scaffolds. According to obtained results, the OsvehOss scaffold seems to be a suitable bio-ceramic and strongly an osteo-conductive bone substitute which could serve as a useful novel bone substitute material for future bone defect treatments.

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