Entropy is a widely used information-theoretic measure; however, the estimation of entropy for observations of a periodic nature has not received much attention thus far. In this paper, we implement a Bayesian approach to obtain nonparametric estimates of Shannon entropy for toroidal data. This paves the way for its use in protein structure validation through an approach based on information theory and the distribution of backbone dihedral angles in the 3D structure of proteins. In addition, the kernel density estimation proposed in this paper can be applied alongside available parametric models for modeling toroidal observations. Simulation studies and the analysis of real datasets provide insights into this proposed method for protein structure validation.

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