Background & aim: Endometriosis is one of the most common chronic inflammatory diseases of women that have destructive effects on sexual function. Therefore, need for counselling about sexual health is part of the treatment of these patients. The present study was designed to examine the effect of cognitive-behavioral counselling on the sexual satisfaction of women with endometriosis. Methods: This clinical trial was conducted on 99 women with endometriosis referring to the clinic of a teaching hospital and a gynecology clinic in Mashhad, Iran from March 2022 to May 2023. Patients were selected through convenience sampling and divided into intervention and control groups using permutation blocks. Subjects in the intervention group received seven online cognitive-behavioral therapy sessions for 60-90 minutes weekly. Control group received routine care. Data were collected using sexual satisfaction scale for women (SSSW) in three stages including before, immediately, and one month after the intervention using independent t-tests, Mann-Whitney, chi-square, and Fisher\\\\\\\\\\\\\\\'s exact tests. The data were analyzed by SPSS software (version 25). Conclusion: Since cognitive-behavioral therapy was effective in increasing sexual satisfaction of women with endometriosis, it is suggested to incorporate this approach in the educational programs tailored for reproductive health of women with endometriosis.

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