Title : ( Ellagic Acid‐Zinc Oxide Nanoparticles Show Antioxidant, Antibacterial Activities and Induce Apoptosis in Lung Cancer A549 Cells )
Authors: farkhonde ghonche moghadam , Ahmad Asoodeh , ABBAS VAEZIKAKHKI ,
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Abstract
Cancer is one of the biggest causes of death in today\\\\\\\\\\\\\\\'s world. In the field of cancer treatment, the use of natural compounds has attracted the attention of researchers. A variety of nanoparticles, including zinc oxide nanoparticles, represent a widely utilized therapeutic approach today due to their exceptional biocompatibility and safety profile. In this study, ellagic acid, which is a natural polyphenolic compound, was used together with synthesized zinc oxide nanoparticles. The loading of ellagic acid in zinc oxide nanoparticles was confirmed by FT-IR and XRD methods. Examination of the viability of A549 cancer cells showed that the cytotoxicity of nano drug Ellagic acid-Zno nanoparticle (EAN) is more than that of ellagic acid alone. The percentage of reac- tive oxygen species (ROS) produced by EAN was higher than that of ellagic acid. Apoptosis was observed in the treated cells by acridine-orange-ethidium-bromide staining. Investigating the cell migration of EAN caused a decrease in cell migration. Based on the research, suggested that EAN can be used as multifunctional nanomedicine nanoparticles.
Keywords
cell cycle | ellagic acid | oxidized nanoparticles | reactive oxygen species
@article{paperid:1103760,
author = {Ghonche Moghadam, Farkhonde and Asoodeh, Ahmad and VAEZIKAKHKI, ABBAS},
title = {Ellagic Acid‐Zinc Oxide Nanoparticles Show Antioxidant, Antibacterial Activities and Induce Apoptosis in Lung Cancer A549 Cells},
journal = {Journal of Biomedical Materials Research Part B: Applied Biomaterials},
year = {2025},
volume = {113},
number = {8},
month = {July},
issn = {1552-4973},
keywords = {cell cycle | ellagic acid | oxidized nanoparticles | reactive oxygen species},
}
%0 Journal Article
%T Ellagic Acid‐Zinc Oxide Nanoparticles Show Antioxidant, Antibacterial Activities and Induce Apoptosis in Lung Cancer A549 Cells
%A Ghonche Moghadam, Farkhonde
%A Asoodeh, Ahmad
%A VAEZIKAKHKI, ABBAS
%J Journal of Biomedical Materials Research Part B: Applied Biomaterials
%@ 1552-4973
%D 2025
