Title : ( Efficient solvent- and catalyst-free one-pot synthesis of novel trifluoromethylated pyrazole derivatives )
Authors: Zhila Zharf Zaki , Abbas Ali Esmaeili ,
Full TextAbstract
A novel and efficient one-pot, three-component reaction was developed for the synthesis of 2-phenyl-4-((arylamino)methylene)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one derivatives. The reaction proceeds via the condensation of 1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one, aniline derivatives, and trimethyl orthoformate under solvent-free conditions at 110 °C. This green protocol integrates multiple pharmacophores, offering potential for biological applications. Key advantages include operational simplicity, high yields (80%–92%), and the absence of catalysts and solvents. IR,1H,1³C, 19F NMR, mass spectrometry, and elemental analysis confirmed product structures.
Keywords
, Green chemistry; one-pot reaction; solvent-free; 1-phenyl-3-(tri@uoromethyl)-1H-pyrazol-5(4H)-one; 2-phenyl-4-((arylamino)methylene)-5-(tri@uoromethyl)-2, 4-dihydro-3H-pyrazol-3-one
@article{paperid:1103990,
author = {Zharf Zaki, Zhila and Esmaeili, Abbas Ali},
title = {Efficient solvent- and catalyst-free one-pot synthesis of novel trifluoromethylated pyrazole derivatives},
journal = {Synthetic Communications},
year = {2025},
month = {August},
issn = {0039-7911},
keywords = {Green chemistry; one-pot reaction; solvent-free; 1-phenyl-3-(tri@uoromethyl)-1H-pyrazol-5(4H)-one;
2-phenyl-4-((arylamino)methylene)-5-(tri@uoromethyl)-2;4-dihydro-3H-pyrazol-3-one},
}
%0 Journal Article
%T Efficient solvent- and catalyst-free one-pot synthesis of novel trifluoromethylated pyrazole derivatives
%A Zharf Zaki, Zhila
%A Esmaeili, Abbas Ali
%J Synthetic Communications
%@ 0039-7911
%D 2025
