Experimental Gerontology, Volume (162), Year (2022-6) , Pages (111756-11766)

Title : ( Improvement of inflammatory status following saffron (Crocus sativus L.) and resistance training in elderly hypertensive men: A randomized controlled trial )

Authors: Shima Mojtahedi , Babak Hooshmand-Moghadam , Sara Rosenkranz , Ziba Shourideh , Farahnaz Amirshaghaghi , Fatemeh Shabkhiz ,

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Abstract

Objective: We sought to determine the independent and combined effects of saffron and resistance training on markers of inflammation and cardiovascular risk factors in elderly hypertensive patients. Methods: Hypertensive older men were randomly assigned to a control group (C) or one of three experimental groups [saffron consumption (S), resistance training (R), and resistance training + saffron (RS)] for 12 weeks. Inflammatory markers and lipid profiles were measured at baseline and following the 12-week intervention period. Patients in S and RS received one tablet containing 200 mg of saffron daily. Primary outcomes were analyzed using univariate analysis of covariance (ANCOVA). Results: The RS group had significantly greater reductions in leptin, resistin, MCP-1, and IL-6 as compared with the C, S, and R groups (ps < 0.05). In addition, the RS, S, and R groups had significantly greater reductions in TC and greater increases in HDL-c as compared with the C group (ps < 0.05), but there were no differences between the RS, S, and R groups. Finally, there were no differences between groups for TNF-α, homocysteine, and hs-CRP (ps > 0.05). Conclusion: Combining Saffron and resistance training can reduce inflammation and cardiovascular disease risk factors associated with increased risk for hypertension in older men with hypertension.

Keywords

Cardiovascular risk factors; Hypertensive elderly men; Inflammatory markers; Resistance training; Saffron.
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@article{paperid:1104225,
author = {شیما مجتهدی and Hooshmand-Moghadam, Babak and سارا روزنکرانز and زیبل شوریده and فرهناز امیرشقاقی and فاطمه شب خیز},
title = {Improvement of inflammatory status following saffron (Crocus sativus L.) and resistance training in elderly hypertensive men: A randomized controlled trial},
journal = {Experimental Gerontology},
year = {2022},
volume = {162},
month = {June},
issn = {0531-5565},
pages = {111756--11766},
numpages = {-99990},
keywords = {Cardiovascular risk factors; Hypertensive elderly men; Inflammatory markers; Resistance training; Saffron.},
}

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%0 Journal Article
%T Improvement of inflammatory status following saffron (Crocus sativus L.) and resistance training in elderly hypertensive men: A randomized controlled trial
%A شیما مجتهدی
%A Hooshmand-Moghadam, Babak
%A سارا روزنکرانز
%A زیبل شوریده
%A فرهناز امیرشقاقی
%A فاطمه شب خیز
%J Experimental Gerontology
%@ 0531-5565
%D 2022

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