This study evaluated the effects of resistance training (RT) combined with creatine hydrochloride (CrHCL) and creatine monohydrate (CrM) supplementation on oxidative stress-antioxidant markers in trained women. In this study, 48 young trained women were selected and randomly assigned to four groups via a double-blind method: Group 1: RT + Creatine hydrochloride (Cr-HCL) supplementation (n = 12), Group 2: RT + Creatine monohydrate-loading phase (CrM-LP) supplementation (n = 12), Group 3: RT + CrM-without loading phase (CrM-WLP) supplementation (n = 12), and Group 4: RT + Placebo (PL) supplementation (n = 12). The RT program was performed for eight weeks with three sessions per week. Blood samples were obtained before and after training to evaluate serum levels of 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) activity. Statistical analyses were performed using the Mixed ANOVA and Bonferroni post-hoc tests at a significance level of 0.05. Following the intervention, the RT + Cr-HCL, RT + CrM-LP, and RT + CrM-WLP supplementation groups indicated significant decreases and increases in the blood levels of MDA and SOD, respectively, compared to the RT + PL supplementation group ( P < 0.05). Likewise, compared with the RT + PL supplementation group, the RT + Cr-HCL, RT + CrM-LP, and RT + CrM-WLP supplementation groups showed a greater decrease and increase in the levels of serum 8-OHdG (effect size [ES] = 1.11, 0.75, 0.66 vs 0.40) and serum GPX (ES = 0.46, 0.71, 0.56 vs 0.08), respectively ( P < 0.05). However, CAT did not change significantly after eight weeks of training in any group. In general, the results showed that Cr-HCl and CrM, along with RT can positively affect oxidative stress-antioxidant indices in trained women. According to the results, Cr-HCl does not cause more effects than CrM.

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