Multicomponent reactions (MCRs) have emerged as pivotal tools in contemporary chemical synthesis, facilitating efficient and sustainable production routes by utilizing readily available starting materials. This study introduces a novel heterogeneous catalyst system by incorporating heteropolyacid (H3PW12O40, HPA) into the UiO-66-NH2 framework (UiO-66-NH2/HPA) via an ionic post-synthetic modification strategy and investigates its catalytic activity in the synthesis of 1-amidoalkyl-2-naphthols. These compounds, renowned for their diverse biological activities, were successfully synthesized using the unique structural properties and catalytic prowess of UiO-66- NH2/HPA through MCRs under mild conditions. The primary advantage of this catalyst lies not only in the Brønsted acidic activity of the HPA but also in the Lewis acidic activity of the support material, in addition to the HPA. Our findings showcase the catalysts’ exceptional efficiency, high yields, and recyclability, underscoring their potential for sustainable and eco-friendly synthesis processes.

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