European Journal of Pharmacology, ( ISI ), Volume (567), No (2), Year (2007-7) , Pages (95-101)

Title : Nifedipine suppresses morphine-induced thermal hyperalgesia: Evidence for the role of corticosterone ( Nifedipine suppresses morphine-induced thermal hyperalgesia: Evidence for the role of corticosterone )

Authors: Saeed Esmaeili-Mahani , Masoud Fereidoni , Mohammad Javan , Nader Maghsoudi , Fereshteh Motamedi , Abolhasan Ahmadiani ,

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Abstract

It has been shown that systemic administration of morphine induced a hyperalgesic response at an extremely low dose. We have examined the effect of nifedipine, as a calcium channel blocker, on morphine-induced hyperalgesia in intact and adrenalectomized rats and on hypothalamic-pituitary-adrenal axis activity induced by ultra-low dose of morphine. To determine the effect of nifedipine on hyperalgesic effect of morphine, nifedipine (2 mg/kg i.p. and 10 microg i.t.) that had no nociceptive effect, was injected concomitant with morphine (1 microg/kg i.p. and 0.01 microg i.t. respectively). The tail-flick test was used to assess the nociceptive threshold, before and 30, 60, 120, 180, 240 and 300 min after drug administration. The data showed that low dose morphine systemic administration could produce hyperalgesic effect in adrenalectomized rats equivalent to sham-operated animals while intrathecal injection of morphine only elicited hyperalgesia in sham-operated animals. Nifedipine could block morphine-induced hyperalgesia in sham and adrenalectomized rats and even a mild analgesic effect was observed in the adrenalectomized group which was reversed by corticosterone replacement. Systemic administration of low dose morphine produced significant increase in plasma level of corticosterone. Nifedipine has an inhibitory effect on morphine-induced corticosterone secretion. Thus, the data indicate that dihydropyridine calcium channels are involved in ultra-low dose morphine-induced hyperalgesia and that both the pattern of morphine hyperalgesia and the blockage of it by nifedipine are modulated by manipulation of the hypothalamic pituitary adrenal axis.

Keywords

, Morphine; Hyperalgesia; L, type calcium channel; Nifedipine; Corticosterone
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@article{paperid:203659,
author = {Saeed Esmaeili-Mahani and Fereidoni, Masoud and Mohammad Javan and Nader Maghsoudi and Fereshteh Motamedi and Abolhasan Ahmadiani},
title = {Nifedipine suppresses morphine-induced thermal hyperalgesia: Evidence for the role of corticosterone},
journal = {European Journal of Pharmacology},
year = {2007},
volume = {567},
number = {2},
month = {July},
issn = {0014-2999},
pages = {95--101},
numpages = {6},
keywords = {Morphine; Hyperalgesia; L-type calcium channel; Nifedipine; Corticosterone},
}

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%0 Journal Article
%T Nifedipine suppresses morphine-induced thermal hyperalgesia: Evidence for the role of corticosterone
%A Saeed Esmaeili-Mahani
%A Fereidoni, Masoud
%A Mohammad Javan
%A Nader Maghsoudi
%A Fereshteh Motamedi
%A Abolhasan Ahmadiani
%J European Journal of Pharmacology
%@ 0014-2999
%D 2007

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