Calorie restriction (CR) in mammals has been recognized as the best characterized and most reproducible strategy for extending maximum survival, retardin physiological aging, and delaying the onset of age-related pathologic conditions in mammals. CR retards the rate of the aging process and extends maximum life span in rodents such as mice and rats. CR is reported to have many advantages and it leads to suppression of obesity, decreases free radicals damages, increases available antioxidants, induction of heat shock proteins, decreases toxicity and lethality of various toxic chemicals and drugs, and suppression of certain types of cancer. Many studies using this manipulation have been done to examine the key concept of \\\\\\\"undernutrition without malnutrition\\\\\\\". This study was conducted to investigate the influence of short-term repeated fasting ( 4 consecutive days, every 2 weeks and this regimen repeated 4 times prior to wound creation) on the skin wound healing of female suri mice. Evaluation of wound healing was performed by macroscopic( Scion image software) as well as microscopic (statistical analysis of specific stained slides scores) examination. The results obtained in this study revealed that the wounds of fasting group healed sooner than the full-fed group.

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