Stress-The International Journal on the Biology of Stress, ( ISI ), Volume (13), No (3), Year (2010-1) , Pages (276-280)

Title : ( Acute Restraint Stress Increases the Frequency of Vinblastin- induced Micronuclei in Mouse Bone Morrow Cells )

Authors: Amir Mohammad Malvandi , Farhang Haddad , Ali Moghimi ,

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Acute physiological stress induces remarkable effects on the nervous, endocrine, and immune systems and also on cellular metabolism and cell division processes. Stress-induced instability of cellular mechanisms might play an important role in increasing cell division disorders. In this study, a relationship between stress and micronucleus (MN) induction in mouse (balb/c) bone marrow cells following vinblastine treatment, or stress or stress and vinblastine treatment in comparison to a non-stressed control group was investigated. In order to test the effects of treatments on MN induction, an in vivo MN assay was performed on bone marrow cells. The results revealed a significantly greater increase in MNs in bone marrow cells (polychromatic erythrocytes) from the stressed/vinblastine treated mice. The data indicate the ability of exposure to an emotional stressor to enhance the damaging actions on bone marrow cells of an aneugenic agent.

Keywords

Acute restraint
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@article{paperid:1011714,
author = {Malvandi, Amir Mohammad and Haddad, Farhang and Moghimi, Ali},
title = {Acute Restraint Stress Increases the Frequency of Vinblastin- induced Micronuclei in Mouse Bone Morrow Cells},
journal = {Stress-The International Journal on the Biology of Stress},
year = {2010},
volume = {13},
number = {3},
month = {January},
issn = {1025-3890},
pages = {276--280},
numpages = {4},
keywords = {Acute restraint stress},
}

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%0 Journal Article
%T Acute Restraint Stress Increases the Frequency of Vinblastin- induced Micronuclei in Mouse Bone Morrow Cells
%A Malvandi, Amir Mohammad
%A Haddad, Farhang
%A Moghimi, Ali
%J Stress-The International Journal on the Biology of Stress
%@ 1025-3890
%D 2010

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