Title : ( Study of Thr149Met mutation in Glucagon-like peptide 1 receptor gene in Mashhad population )
Authors: Samaneh Sepahi , , Razieh Jalal , Jamshid Darvish ,
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Abstract
In this study, 100 patients with type 2 diabetes and 50 controls were screened by RFLP-PCR. For the detected polymorphisms, genomic DNA was extracted from control and type 2 diabetic subjects. Exon 5 of human GLP-1R gene was amplified by the PCR. The PCR products of exon 5 were digested by NLaIII restriction endonuclease and analyzed on the agarose gel. The GLP-1R By PCR-RFLP using the NLaIII fragment we were able to clearly distinguish, the Thr149Met mutation was absent in all patients and controls. There is no relation between Thr149Met polymorphism and diabetic disease manifestation in Mashhad.
Keywords
, Thr149Met mutation, Glucagon-like peptide 1 receptor gene, Mashhad population
@inproceedings{paperid:1018682,
author = {Sepahi, Samaneh and , and Jalal, Razieh and Darvish, Jamshid},
title = {Study of Thr149Met mutation in Glucagon-like peptide 1 receptor gene in Mashhad population},
booktitle = {دومین کنگره بین المللی سندرم متابولیک، چاقی و دیابت},
year = {2010},
location = {زنجان, IRAN},
keywords = {Thr149Met mutation; Glucagon-like peptide 1 receptor gene; Mashhad population},
}
%0 Conference Proceedings
%T Study of Thr149Met mutation in Glucagon-like peptide 1 receptor gene in Mashhad population
%A Sepahi, Samaneh
%A ,
%A Jalal, Razieh
%A Darvish, Jamshid
%J دومین کنگره بین المللی سندرم متابولیک، چاقی و دیابت
%D 2010
