Aspirin is a drug with many effects such as antiinflamatory and antinociceptive effects in mammalian but its effects on insects must be studid more .In this study ,Drosophila larva was used in thermal ) Hot plate (and chemical ) Writhing ( method and Adult drosophila was used in thermal method. 3rd stage of D .melanogaster larvae and Adult drosophila was used).n=10 .(In thermal pain test the number of rolling movment in drosophila larva )in 47ºC (was compared between control and test group with different concentrations of aspirin )0/15-5gr/lit .(The same in chemical pain which induced by acetic acid solution )40 (%performed The effect of, oral aspirin treatment on thermal pain for adult drosophila was recorded using the latency period. Aspirin concentrations 5,2/5,1/2 gr/lit )p<0/001(, 0/6 gr/lit )p<0/01(, 0/3 gr/lit )p<0/05 (decreasd number of rolling movments on 47ºC and so pain .Aspirin concentration 0/01-5 gr/lit decerasd chemical pain )on acetic acid 40 ) .(%p<0/001( and the most effective concentrations of aspirin were 0/05 gr/lit antil 0/3 gr/lit .In adult drosophila , concentration 5, 10 gr/lit induced maximum analgesic effect ) .p<0/001). In thermal and chemical pain models, different concemtration of aspirin, showed good analgesic action, perhaps, at teast in part, inhibition of inflammatory reaction through block of cox2 enzyme )with a mechanism similar mammalian (is responsible for inpart of analgesic effects of aspirin , it needs to studied more .regard to aspirin effect on both thermal and chemical pain, the drug may shows its inhibitory effects through the central as well as the peripheral nociception mechanisms.

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