Chromatographia, ( ISI ), Volume (73), No (3), Year (2011-3) , Pages (549-557)

Title : ( Separation and Determination of Amitriptyline and Nortriptyline in Biological Samples Using Single-Drop Microextraction with GC )

Authors: Ali Sarafraz Yazdi , ,

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Abstract The combination of liquid phase microextraction (LPME) based on a single drop and gas chromatography flame ionization detector (GC-FID) was used for separation and determination of amitriptyline and nortriptyline in human plasma and urine samples. The sample solution was kept alkaline (pH 12), then a microdrop of organic solvent (isooctane) was suspended in the donor solution; after extraction, the organic microdrop was injected into the GC-FID. Experimental LPME conditions were optimized. Finally, the enrichment factors (89.5–139.0), the relative standard deviation (RSD%, n = 5) 1.1–8.5, linearity ranges (0.05–20 lg mL-1), and the limits of detections (0.01, 0.02 lg mL-1) for selected drugs were evaluated.

Keywords

, Keywords Gas chromatography  Single, drop liquidphase microextraction  Amitriptyline  Nortriptyline  Biological
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@article{paperid:1020735,
author = {Sarafraz Yazdi, Ali and , },
title = {Separation and Determination of Amitriptyline and Nortriptyline in Biological Samples Using Single-Drop Microextraction with GC},
journal = {Chromatographia},
year = {2011},
volume = {73},
number = {3},
month = {March},
issn = {0009-5893},
pages = {549--557},
numpages = {8},
keywords = {Keywords Gas chromatography  Single-drop liquidphase microextraction  Amitriptyline  Nortriptyline  Biological sample},
}

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%0 Journal Article
%T Separation and Determination of Amitriptyline and Nortriptyline in Biological Samples Using Single-Drop Microextraction with GC
%A Sarafraz Yazdi, Ali
%A ,
%J Chromatographia
%@ 0009-5893
%D 2011

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