Introduction: Agouti-related peptide is a neuropeptide produced in the arcuate nucleus of hypothalamus and has important role in central controlling of food intake and appetite. The purpose of the present study was to compare the effect of two types of exercises, aerobic and anaerobic, on plasma intensity of female students. Methodology and Procedures: Thirty female students of physical education were voluntary selected (Age= 22/73±1/97; Weight= 56/6±5/8 kg; Height= 162±4/57 and Body Mass Index (BMI) =17/48±1/73 kg/m². Then they were randomly divided into two experimental groups (15 aerobic and 15 anaerobic) and exercised for 4 weeks. Blood samples were taken in two periods (24 hours before exercise protocol and after the last session of exercise). Plasma AGRP values were measured according to ELISA method. Results: There was a significant increase of Plasma AGRP concentration in two groups after 4 weeks of training. Also, there was no significant difference between the effect of cooper aerobic exercise and running based anaerobic sprint test (RAST) on Plasma AGRP concentration ratio. Conclusion: It seems that plasma AGRP increase could be associated with the increase of this peptide in hypothalamus and in response to the negative balance of energy produced by exercising for increasing appetite to compensate energy resources of testers’ body.

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