Iranian Journal of Veterinary Surgery, Volume (3), No (4), Year (2011-6) , Pages (19-29)

Title : ( Efficacy of Autologous Platelet-Rich Plasma (PRP) Activated By Thromboplastin-D on the Repair and Regeneration of Wounds in Dogs )

Authors: Hossein Kazemi Mehrjerdi , Kamran Sardari , Mohammadreza Emami , Ahmad Reza Movassaghi , Amir Afkhami Goli , , Sara Malekzadeh ,

Citation: BibTeX | EndNote

Objective- To evaluate the effects of autologous platelet-rich plasma (PRP) on wound healing in dogs. Design- Experimental in-vivo study. Animals- 5 mix-breed male adult dogs. Procedures- Under general anesthesia, six 2 × 2-cm, full-thickness skin wounds were created on the back of dogs symmetrically. In each dog, three right side wounds were treated topically with 1.5 ml PRP jelly, whereas left side wounds received no treatment. For macroscopic evaluation, at days 0, 3, 5, 7, 10, 13, 17, 20, and 24, digital photographs were taken from wounds. At days 10, 17 and 24 after wounding, skin biopsies were taken from the center and corner of each wound for hydroxyprolin measurement and histopathologic evaluation respectively. Results- No statistically significant differences were found in percentage of wound contraction, epithelialization and healing between test and control group during study (P>0.05). There were no significant differences between median of hydroxyprolin levels, median of inflammatory cells infiltration, presence of dermal granulation tissue, fibroblast proliferation, arrangement of fibroblasts, collagen deposition and collagen bundle formation scores, in the specimens from left and right wounds (P>0.05). Conclusion and Clinical Relevance- Topical application of platelet-rich plasma can not accelerate repair of the small granulating wounds of dogs.

Keywords

, Dog, Wound healing, Platelet- rich plasma, Growth
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@article{paperid:1026251,
author = {Kazemi Mehrjerdi, Hossein and Sardari, Kamran and Emami, Mohammadreza and Movassaghi, Ahmad Reza and Afkhami Goli, Amir and , and Malekzadeh, Sara},
title = {Efficacy of Autologous Platelet-Rich Plasma (PRP) Activated By Thromboplastin-D on the Repair and Regeneration of Wounds in Dogs},
journal = {Iranian Journal of Veterinary Surgery},
year = {2011},
volume = {3},
number = {4},
month = {June},
issn = {2008-3033},
pages = {19--29},
numpages = {10},
keywords = {Dog; Wound healing; Platelet- rich plasma; Growth factors.},
}

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%0 Journal Article
%T Efficacy of Autologous Platelet-Rich Plasma (PRP) Activated By Thromboplastin-D on the Repair and Regeneration of Wounds in Dogs
%A Kazemi Mehrjerdi, Hossein
%A Sardari, Kamran
%A Emami, Mohammadreza
%A Movassaghi, Ahmad Reza
%A Afkhami Goli, Amir
%A ,
%A Malekzadeh, Sara
%J Iranian Journal of Veterinary Surgery
%@ 2008-3033
%D 2011

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