Natural Product Research, ( ISI ), Volume (26), No (18), Year (2012-9) , Pages (1724-1727)

Title : ( Increasing the cisplatin cytotoxicity and cisplatin-induced DNA damage by conferone in 5637 cells )

Authors: Vajiheh Neshati , Maryam Moghaddam Matin , Ahmad Reza Bahrami , Mehrdad Iranshahi , Fatemeh Behnam Rassouli , ,

Citation: BibTeX | EndNote

Despite widespread application of cisplatin in treatment of transitional cell carcinomas, its efficiency is far from satisfactory due to acquired drug resistance. The present study was carried out to estimate the effects of conferone, a sesquiterpene-coumarin isolated from Ferula badrakema , on increasing cisplatin cytotoxicity in 5637 cells. In order to determine conferone effects, 5637 cells were cultured in the presence of different concentrations of conferone and cisplatin in combination. The cytotoxicity and DNA damaging effects were then studied using MTT and comet assays, respectively. The results revealed that 24 h after the combination of 1 mgmL1 cisplatin with 32 mgmL1 conferone, the cytotoxicity of cisplatin was increased by 36.76%, and comet assay analyses showed that conferone could enhance the DNA damaging effects of cisplatin by 41%.

Keywords

, conferone; sesquiterpene, coumarin; cisplatin; cytotoxicity; 5637
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

@article{paperid:1029351,
author = {Neshati, Vajiheh and Moghaddam Matin, Maryam and Bahrami, Ahmad Reza and Mehrdad Iranshahi and Behnam Rassouli, Fatemeh and , },
title = {Increasing the cisplatin cytotoxicity and cisplatin-induced DNA damage by conferone in 5637 cells},
journal = {Natural Product Research},
year = {2012},
volume = {26},
number = {18},
month = {September},
issn = {1478-6419},
pages = {1724--1727},
numpages = {3},
keywords = {conferone; sesquiterpene-coumarin; cisplatin; cytotoxicity; 5637 cells},
}

[Download]

%0 Journal Article
%T Increasing the cisplatin cytotoxicity and cisplatin-induced DNA damage by conferone in 5637 cells
%A Neshati, Vajiheh
%A Moghaddam Matin, Maryam
%A Bahrami, Ahmad Reza
%A Mehrdad Iranshahi
%A Behnam Rassouli, Fatemeh
%A ,
%J Natural Product Research
%@ 1478-6419
%D 2012

[Download]