African Journal of Microbiology Research, ( ISI ), Volume (6), No (30), Year (2012-8) , Pages (6001-6005)

Title : ( Age-dependent response to CpG oligodeoxynucleotides against organ invasion of Salmonella enteritidis in broiler chickens )

Authors: vahideh shahrokhi , Mehrnaz Rad , Gholam ali Kalidari ,

Access to full-text not allowed by authors

Citation: BibTeX | EndNote

Abstract

Bacterial infections cause significant economic losses in the broiler industry throughout the production cycle. It is known that CpG-ODN stimulated innate immune activities and enhanced the resistance to infectious pathogens in chickens. In this study, the effectiveness of CpG-ODN was evaluated in organ colonization by Salmonella enteritidis at different ages of chickens. Pre-treatment of 2-day old chickens with CpG-ODN by subcutaneous injection and subsequent challenge with S. enteritidis 3 h after treatment resulted in significant reduction of organ invasion by S. enteritidis. In a second experiment, these chickens were repeatedly treated with CpG-ODN at day 20, and 24 h later were orally infected with S. enteritidis. There was no significant reduction in organ invasion by S. enteritidis compared to PBS treated controls. In a third experiment, five-day old chickens were treated with CpG-ODN and 24 h later orally infected with S. enteritidis. There was no reduction in organ invasion compared to PBS treated control group. Our study shows that CpG-ODN increase resistance against S. enteritidis invasion in broiler chicken in early age.

Keywords

, CpG-ODN, Salmonella enteritidis, immunoprotection, poultry.
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

@article{paperid:1030123,
author = {Shahrokhi, Vahideh and Rad, Mehrnaz and Kalidari, Gholam Ali},
title = {Age-dependent response to CpG oligodeoxynucleotides against organ invasion of Salmonella enteritidis in broiler chickens},
journal = {African Journal of Microbiology Research},
year = {2012},
volume = {6},
number = {30},
month = {August},
issn = {1996-0808},
pages = {6001--6005},
numpages = {4},
keywords = {CpG-ODN; Salmonella enteritidis; immunoprotection; poultry.},
}

[Download]

%0 Journal Article
%T Age-dependent response to CpG oligodeoxynucleotides against organ invasion of Salmonella enteritidis in broiler chickens
%A Shahrokhi, Vahideh
%A Rad, Mehrnaz
%A Kalidari, Gholam Ali
%J African Journal of Microbiology Research
%@ 1996-0808
%D 2012

[Download]