Summary Aim of present study was investigating the effects of 8-weeks of aerobic training program on plasma levels of adiponectin and leptin in healthy middle-aged men. Methods. — For this purpose, thirty middle-aged healthy men were selected and depended on their body fat percentage were assigned in two equal groups. Experimental group performed 8-weeks aerobic training 4 days a week in alteration days with 60—80 percentage of maximum heart rate and control group remained sedentary. Blood samples were collected prior to and after training program for all subjects and plasma adipokines levels were measured. Results. — Results showed a significant increase in adiponectin and resistin concentrations, also a decrease in leptin concentrations following 8-weeks of aerobic training program ( P < 0.05). In addition, reduction in body fat percentage ( P < 0.05) negatively correlated with adiponectin and resistin levels ( P < 0.05) and positively correlated with leptin levels ( P < 0.05). Conclusion. — In healthy middle-aged men, 8-weeks of aerobic training reduced body fat percentage and improved plasma adipokines levels, so aerobic training can considered as major strategies for preventing obesity and associated diseases.

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