Title : ( Diastereoselective three-component Mannich reaction catalyzed by silica-supported ferric hydrogensulfate )
Authors: Hossein Eshghi , Mohammad Rahimizadeh , Mohsen Hosseini , Aida Javadian Saraf ,
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Abstract
A highly anti-diastereoselective three-component Mannich reaction of aromatic amines and aromatic aldehydes with cyclohexanone in the presence of silicasupported ferric hydrogensulfate has been developed. The best selectivity was obtained where there were electrondonating groups on both aldehyde and amine. Selectivity decreases when electron-withdrawing groups are present on the aldehyde; in these cases selectivity is improved if an electron-donating group is present on the amine.
Keywords
, Three-component, Diastereoselective anti-Mannich reaction, Silica-supported ferric hydrogensulfate, Iron heterogeneous catalysis
@article{paperid:1031110,
author = {Eshghi, Hossein and Rahimizadeh, Mohammad and Hosseini, Mohsen and Javadian Saraf, Aida},
title = {Diastereoselective three-component Mannich reaction catalyzed by silica-supported ferric hydrogensulfate},
journal = {Monatshefte fur Chemie},
year = {2013},
volume = {144},
number = {2},
month = {February},
issn = {0026-9247},
pages = {197--203},
numpages = {6},
keywords = {Three-component; Diastereoselective anti-Mannich reaction; Silica-supported ferric hydrogensulfate;
Iron heterogeneous catalysis},
}
%0 Journal Article
%T Diastereoselective three-component Mannich reaction catalyzed by silica-supported ferric hydrogensulfate
%A Eshghi, Hossein
%A Rahimizadeh, Mohammad
%A Hosseini, Mohsen
%A Javadian Saraf, Aida
%J Monatshefte fur Chemie
%@ 0026-9247
%D 2013
