Journal of the Brazilian Chemical Society, ( ISI ), Volume (23), No (12), Year (2012-12) , Pages (2197-2203)

Title : ( A novel approach for the synthesis of 5-substituted-1H-tetrazoles )

Authors: Batool Akhlaghinia , ,

Citation: BibTeX | EndNote

A series of 5-substituted-1H-tetrazoles (RCN4H) have been synthesized by cycloaddition reaction of different aryl and alkyl nitriles with sodium azide in DMSO using CuSO4•5H2O as catalyst. A wide variety of aryl nitriles underwent [3+2] cycloaddition to afford tetrazoles under mild reaction conditions in good to excellent yields. The catalyst used is readily available and environmentally friendly. Short reaction times, good to excellent yields, safe process and simple workup make this method an attractive and useful contribution to present organic synthesis of 5-substituted-1H-tetrazoles.

Keywords

, 5-substituted-1H-tetrazole, arylnitriles, sodium azide, CuSO4•5H2O, cycloaddition
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@article{paperid:1032228,
author = {Akhlaghinia, Batool and , },
title = {A novel approach for the synthesis of 5-substituted-1H-tetrazoles},
journal = {Journal of the Brazilian Chemical Society},
year = {2012},
volume = {23},
number = {12},
month = {December},
issn = {0103-5053},
pages = {2197--2203},
numpages = {6},
keywords = {5-substituted-1H-tetrazole; arylnitriles; sodium azide; CuSO4•5H2O; cycloaddition reaction},
}

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%0 Journal Article
%T A novel approach for the synthesis of 5-substituted-1H-tetrazoles
%A Akhlaghinia, Batool
%A ,
%J Journal of the Brazilian Chemical Society
%@ 0103-5053
%D 2012

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