Background: Leptin resistance is one of the influential factors on hyperinsuhnisrn and finally on lack of the glucose tolerance in overweight and its related diseases. Thus the goal of this research is to study the response of Leplin Plasnra. 17-bela estradiol serum and insulin to 24-weeks aerobic exerctse In inactive obese women. Method: The research was of semi-experimental kind 15 inactive obese women were chosen randontly and were categorized in two different groups, i.e. aerr:bic exercise and control. The exercise process included aerobic exercises for 6 months (three 60-minute sessions per week).we used repeated measure for variation the. time x group. The Independent sample T test was applied tct cornpare the average amounts betwecrr groLtps. Result: The results represent that the influence of time has not been identical orr arnount of leptin seTum, insulin, the body nrass index and fat amount, and a 24-weeks ac.roDrc exerctse caused a significant decrease in this field (P<0.05). Afler 24-weeks aerobic exerctses, duration of tinte in two different control and aerobrc exercise groups showed no important effect on the level of estradiol serum (P = \\\\\\\'1 7 beta 0 393). Conclusion Results showed that. aerobic exercises reduce the body mass index and consequently reduce leptin and insulin in inactive obese wonren via increasing tlre capacity of ntuscle in using the fat, which can be considered as a preventing factor of obesity and its related diseases, such as obesity and cardiovascular diseases.

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