High tannin diets may increase the clinical symptoms of intoxication in ruminants. Toxic effects are reflected by damage in the liver, kidneys and the epithelium of the digestive tract. Polyethylene glycol (PEG) can neutralize the toxic effects of tannins. The aim of this study was to evaluate the effects of feeding pistachio hull (PH, source of tannin) and PEG supplementation on the liver enzymes i.e., alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and blood factors such as packed cell volume (PCV), mean corpuscular hemoglobin concentration (MCHC), total white blood cells (TWBC), neutrophils, eosinophils, lymphocytes, monocytes, and hemoglobin in Saanen dairy goats. Nine Saanen dairy goats were used in a 3 × 3 Latin square design. Three treatments were formulated: T1) Control, without PH, T2) 30% PH (DM basis) that provided 18.1 g condense tannin per kg DM of diet and T3) 30% PH + 1% PEG (DM basis). In T2 and T3, PH replaced alfalfa hay. Statistical analysis was performed using the MIXED procedure of SAS (P < 0.05). Immune factors and liver enzymes were not significantly affected by the exprimental diets. But, plasma concentration of MCHC and hemoglobin and percentage of PCV in T2 had a tendency to decrease and was removed by PEG addition in T3 (with P = 0.534, P = 0.735 and P = 0.732 for MCHC, hemoglobin and PCV, respectively). Conversely, concentration of ALT and AST and number of TWBC, neutrophil, eosinophil, lymphocyte, and monocyte in T2 had a tendency to increase and was removed by PEG addition in T3 (with P = 0.791, P = 0.931, P = 0.794, P = 0.399, P = 0.928, P = 0.659, P = 0.933 and P = 0.368 for ALT, AST, TWBC, neutrophil, eosinophil, lymphocyte and monocyte, respectively).

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