Abstract Purpose: The aim of this study was to investigate the effects of six months of aerobic training on some renal function markers in untrained middle-aged women. Methods: Nineteen healthy female middle-aged were selected by convenience sampling method and were randomly divided into two experimental (n=11) and control (n=8) groups. The exercise protocol included aerobic exercise training lasted for 6 months and 3 sessions per week and every session lasted for 60 minutes and with intensity of 55-65 percent of maximum heart rate reserve (MHR). Blood samples were taken to measure uric acid, creatinine and BUN before and after aerobic training program .Also, eGFR and BUN-to-creatinine ratio was measured with formula. A general linear-repeated measure was used to comparing of within, interactive and between means groups. The level of significance was set at P< 0.05. Results: Our results showed the changes of weight, BMI, body fat percent, WHR was not significantly. However, findings showed that Uric Acid in the experimental group increased significantly (P<0/05), but the levels of Creatinine, BUN, and eGFR did not change significant. Conclusion: Results showed that six months of aerobic training does not induce significant change in estimated Glomerular Filtration Rate and blood Urea Nitrogen, however, if the aerobic exercise training performs in adequate time and intensity and cause the loss of weight and fat percentage, probably can improve the renal function.

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