Abstract Introduction: Obestatin is recently described as a gastrointestinal (GI) hormonal, which is involved in the pathophysiology of obesity. It decreases food intake and body weight by decelerating gastric emptying. The purpose of this study was to investigate the impact of a single circuit-resistance exercise and aerobic exercise on plasma obestatin and growth hormone (GH) in well-trained females. Material and Methods: 24 participants from Khorasani female athletes were randomly selected and assigned into three groups: control (N=8), circuit-resistance exercise (RE) (N=8) and aerobic exercise (AE) (N=8). Blood samples were collected from all the participants before and immediately after the exercise protocol. Results: Changes in plasma obestatin levels were not significant within and between groups. Plasma GH concentrations were significantly higher in experimental groups compared to the control group. Discussion and Conclusion: The data indicated that although circuit-resistance and aerobic exercise resulted in a significant change in GH levels, they had no effect on plasma obestatin levels.

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