20th Iranian Seminar of Organic Chemistry , 2013-07-03

Title : ( A facile approach for the synthesis of new derivatives of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine )

Authors: seddigheh sheikhi mohammareh , Mohammad Rahimizadeh , Mehdi Bakavoli , Ali Shiri ,

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Abstract

Pyrazolotriazolopyrimidines are a class of fused heterocycles which have interesting pharmacological activities[1]. Several 3- and/or 5-substituted 7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3c]pyrimidines were reported to be potent xanthine oxidase (XO) inhibitors[2].In addition, various derivatives of them have been used as a new pharmacological tool for characterization of human A 3 adenosine receptors[3]. Initially, pyrazolo[3,4-d]pyrimidine (1) was prepared according to previous published method[4] and subsequently treated with POCl and hydrazine hydrate to give the desired compound (2). In continuation, the heterocyclization reaction of compound (2) with some triethylorthoesters in boiling acetic acid gave quantitatively the corresponding new pyrazolotriazolopyrimidine derivatives (3a-c). On the other hand, the reaction of compound (2) with CS 3 in DMF and then various alkylhalides yeilded the new derivatives of pyrazolotriazolopyrimidine (4a-e) in good yields. 2

Keywords

, Pyrazolotriazolopyrimidines are a class of fused heterocycles which have interesting pharmacological activities[1]. Several 3- and/or 5-substituted 7H-pyrazolo[4, 3-e][1, 2, 4]triazolo[4, 3c]pyrimidines were reported to be potent xanthine oxidase (XO) inhibitors[2].In addition, various derivatives of th
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@inproceedings{paperid:1035428,
author = {Sheikhi Mohammareh, Seddigheh and Rahimizadeh, Mohammad and Bakavoli, Mehdi and Shiri, Ali},
title = {A facile approach for the synthesis of new derivatives of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine},
booktitle = {20th Iranian Seminar of Organic Chemistry},
year = {2013},
location = {همدان, IRAN},
keywords = {Pyrazolotriazolopyrimidines are a class of fused heterocycles which have interesting pharmacological activities[1]. Several 3- and/or 5-substituted 7H-pyrazolo[4;3-e][1;2;4]triazolo[4;3c]pyrimidines were reported to be potent xanthine oxidase (XO) inhibitors[2].In addition; various derivatives of them have been used as a new pharmacological tool for characterization of human A 3 adenosine receptors[3]. Initially; pyrazolo[3;4-d]pyrimidine (1) was prepared according to previous published method[4] and subsequently treated with POCl and hydrazine hydrate to give the desired compound (2). In continuation; the heterocyclization reaction of compound (2) with some triethylorthoesters in boiling acetic acid gave quantitatively the corresponding new pyrazolotriazolopyrimidine derivatives (3a-c). On the other hand; the reaction of compound (2) with CS 3 in DMF and then various alkylhalides yeilded the new derivatives of pyrazolotriazolopyrimidine (4a-e) in good yields. 2},
}

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%0 Conference Proceedings
%T A facile approach for the synthesis of new derivatives of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine
%A Sheikhi Mohammareh, Seddigheh
%A Rahimizadeh, Mohammad
%A Bakavoli, Mehdi
%A Shiri, Ali
%J 20th Iranian Seminar of Organic Chemistry
%D 2013

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