20th Iranian Seminar of Organic Chemistry , 2013-07-03

Title : ( Synthesis of new derivatives of pyrimido[5,4-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazine and stadise of their biological activities )

Authors: tayebe asghari shirghan , Mehdi Bakavoli , Mohammad Rahimizadeh , Hossein Eshghi , satar saberi , ,

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Due to their unique clinical applications, syntheses of pyrimidine-fused heterocycles have been intensively investigated in recent years. Pyrimidine derivatives are highly effective as hypnotic drugs, antitumor, antibacterial and anti-HIV agents, and in cancer detection [1-3].Moreover the pyrimido[4,5-e][1,3,4]thiadiazines are a class of heterocyclic compounds, which have been described as anti-hypertensives [4], with enzyme inhibitory activity on soybean 15-lipoxygenase [5]. We now describe the synthesis of some new derivatives of tricyclic pyrimido[5,4-e][1,2,4]triazolo[3,4b][1,3,4]thiadiazines and their enzyme inhibitory activity towards 15-LO (Scheme 1).

Keywords

, Due to their unique clinical applications, syntheses of pyrimidine-fused heterocycles have been intensively investigated in recent years. Pyrimidine derivatives are highly effective as hypnotic drugs, antitumor, antibacterial and anti-HIV agents, and in cancer detection [1-3].Moreover the
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@inproceedings{paperid:1035433,
author = {Asghari Shirghan, Tayebe and Bakavoli, Mehdi and Rahimizadeh, Mohammad and Eshghi, Hossein and Saberi, Satar and , },
title = {Synthesis of new derivatives of pyrimido[5,4-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazine and stadise of their biological activities},
booktitle = {20th Iranian Seminar of Organic Chemistry},
year = {2013},
location = {همدان, IRAN},
keywords = {Due to their unique clinical applications; syntheses of pyrimidine-fused heterocycles have been intensively investigated in recent years. Pyrimidine derivatives are highly effective as hypnotic drugs; antitumor; antibacterial and anti-HIV agents; and in cancer detection [1-3].Moreover the pyrimido[4;5-e][1;3;4]thiadiazines are a class of heterocyclic compounds; which have been described as anti-hypertensives [4]; with enzyme inhibitory activity on soybean 15-lipoxygenase [5]. We now describe the synthesis of some new derivatives of tricyclic pyrimido[5;4-e][1;2;4]triazolo[3;4b][1;3;4]thiadiazines and their enzyme inhibitory activity towards 15-LO (Scheme 1).},
}

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%0 Conference Proceedings
%T Synthesis of new derivatives of pyrimido[5,4-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazine and stadise of their biological activities
%A Asghari Shirghan, Tayebe
%A Bakavoli, Mehdi
%A Rahimizadeh, Mohammad
%A Eshghi, Hossein
%A Saberi, Satar
%A ,
%J 20th Iranian Seminar of Organic Chemistry
%D 2013

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