20th Iranian Seminar of Organic Chemistry , 2013-07-03

Title : ( A novel and efficient one-pot synthesis of new α-aminophosphonates and evaluation of their biologicalactivities )

Authors: Hossein Eshghi , mehdi mirzaei , Mohammad Rahimizadeh ,

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In recent years, considerable interest has been focused on the synthesis of α-aminophosphonates, because they are considered to be structural analogues of the corresponding α-aminoacids.In these connections, the utilities of α-aminophosphonates as anticancer, antibiotics and pharmacologic agents [1-2]. The synthesis of some novel α-aminophosphonates throughan addition of diethyl phosphite to electro-rich aldehyde and different amines[3]. This study represents a three-componentreaction in which no intermediate formation of either an imine or α-hydroxyphosphonate was observed. In this protocol avoids the use of any catalyst, any solvents, and dry reaction conditions.The aaminophosphonates have been characterized by elemental analysis, IR and NMR ( 1 H, 13 C and 3 1P) spectra and X-ray diffraction. Some of these α-aminophosphonates were found to have antitumor activity on the cell lines DU145 in vitro by the MTT method.(Scheme 1)

Keywords

, In recent years, considerable interest has been focused on the synthesis of α-aminophosphonates, because they are considered to be structural analogues of the corresponding α-aminoacids.In these connections, the utilities of α-aminophosphonates as anticancer, antibiotics and pharmacologic agents
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@inproceedings{paperid:1035435,
author = {Eshghi, Hossein and Mirzaei, Mehdi and Rahimizadeh, Mohammad},
title = {A novel and efficient one-pot synthesis of new α-aminophosphonates and evaluation of their biologicalactivities},
booktitle = {20th Iranian Seminar of Organic Chemistry},
year = {2013},
location = {همدان, IRAN},
keywords = {In recent years; considerable interest has been focused on the synthesis of α-aminophosphonates; because they are considered to be structural analogues of the corresponding α-aminoacids.In these connections; the utilities of α-aminophosphonates as anticancer; antibiotics and pharmacologic agents [1-2]. The synthesis of some novel α-aminophosphonates throughan addition of diethyl phosphite to electro-rich aldehyde and different amines[3]. This study represents a three-componentreaction in which no intermediate formation of either an imine or α-hydroxyphosphonate was observed. In this protocol avoids the use of any catalyst; any solvents; and dry reaction conditions.The aaminophosphonates have been characterized by elemental analysis; IR and NMR ( 1 H; 13 C and 3 1P) spectra and X-ray diffraction. Some of these α-aminophosphonates were found to have antitumor activity on the cell lines DU145 in vitro by the MTT method.(Scheme 1)},
}

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%0 Conference Proceedings
%T A novel and efficient one-pot synthesis of new α-aminophosphonates and evaluation of their biologicalactivities
%A Eshghi, Hossein
%A Mirzaei, Mehdi
%A Rahimizadeh, Mohammad
%J 20th Iranian Seminar of Organic Chemistry
%D 2013

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