Title : ( A novel and efficient one-pot synthesis of new α-aminophosphonates and evaluation of their biologicalactivities )
Authors: Hossein Eshghi , mehdi mirzaei , Mohammad Rahimizadeh ,
Full TextAbstract
In recent years, considerable interest has been focused on the synthesis of α-aminophosphonates, because they are considered to be structural analogues of the corresponding α-aminoacids.In these connections, the utilities of α-aminophosphonates as anticancer, antibiotics and pharmacologic agents [1-2]. The synthesis of some novel α-aminophosphonates throughan addition of diethyl phosphite to electro-rich aldehyde and different amines[3]. This study represents a three-componentreaction in which no intermediate formation of either an imine or α-hydroxyphosphonate was observed. In this protocol avoids the use of any catalyst, any solvents, and dry reaction conditions.The aaminophosphonates have been characterized by elemental analysis, IR and NMR ( 1 H, 13 C and 3 1P) spectra and X-ray diffraction. Some of these α-aminophosphonates were found to have antitumor activity on the cell lines DU145 in vitro by the MTT method.(Scheme 1)
