Title : ( Synthesis of new pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives in the presence of ferric hydrogensulfate )
Authors: Aida Javadian Saraf , Hossein Eshghi , Mohammad Rahimizadeh , Maede Hasanpour Mansour ,
Full TextAbstract
Pyrimidopyrimidines are bicyclic uracils that have attracted considerable interest in recent years [1]. Their derivatives have been known to display a wide range of pharmacological activities, and potent inhibitory properties. Numerous reports explain the antitumor,antiviral,antioxidant, antifungal, antiallergic, antihypertensive activities of these compounds [2-3]. In this report new derivatives of pyrimido[4,5-d]pyrimidine have been synthesized in a threecomponent, efficient and green process by condensation reaction of 6-amino-thiouracil, aldehydes and urea or thiourea or guanidine in the presence of ferric hydrogensulfate as catalyst in ethanol under reflux condition.The advantages of this method are high conversion and yield, simple experimental and workup procedure (Scheme 1).
Keywords
, Pyrimidopyrimidines are bicyclic uracils that have attracted considerable interest in recent years [1]. Their derivatives have been known to display a wide range of pharmacological activities, and potent inhibitory properties. Numerous reports explain the antitumor, antiviral, antioxidant, antifungal,
@inproceedings{paperid:1035437,
author = {Javadian Saraf, Aida and Eshghi, Hossein and Rahimizadeh, Mohammad and Hasanpour Mansour, Maede},
title = {Synthesis of new pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives in the presence of ferric hydrogensulfate},
booktitle = {20th Iranian Seminar of Organic Chemistry},
year = {2013},
location = {همدان, IRAN},
keywords = {Pyrimidopyrimidines are bicyclic uracils that have attracted considerable interest in recent years [1]. Their derivatives have been known to display a wide range of pharmacological activities; and potent inhibitory properties. Numerous reports explain the antitumor;antiviral;antioxidant; antifungal; antiallergic; antihypertensive activities of these compounds [2-3].
In this report new derivatives of pyrimido[4;5-d]pyrimidine have been synthesized in a threecomponent; efficient and green process by condensation reaction of 6-amino-thiouracil; aldehydes and urea or thiourea or guanidine in the presence of ferric hydrogensulfate as catalyst in ethanol under reflux condition.The advantages of this method are high conversion and yield; simple experimental and workup procedure (Scheme 1).},
}
%0 Conference Proceedings
%T Synthesis of new pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives in the presence of ferric hydrogensulfate
%A Javadian Saraf, Aida
%A Eshghi, Hossein
%A Rahimizadeh, Mohammad
%A Hasanpour Mansour, Maede
%J 20th Iranian Seminar of Organic Chemistry
%D 2013
