@inproceedings{paperid:1035446,
author = {A. Nikseresht and S. Parak and Bakavoli, Mehdi and J. Lari and H. Vahedi},
title = {A convenient one-pot method for the synthesis of highly functionalized 1,3-oxazole},
booktitle = {20th Iranian Seminar of Organic Chemistry},
year = {2013},
location = {همدان, IRAN},
keywords = {1;3-Oxazole derivatives elicit a variety of biological responses [1-2]; including anti-cancer and anti-HIV/AIDS activity [3]. We now report a more convenient and versatile method for the synthesis of highly substituted N(9-(2-(5-amino-4-cyano-oxazol-2-yl)phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene)-Nethylethanaminium chloridefrom aminomalononitrile tosylate (AMNT; 1)and Rhodamin B such as carboxylic acid derivative. The carboxyl activating reagent; 1;3-dicyclohexylcarbodiimide (DCC); has been used to synthesize 2-substituted 5-amino-4-cyano-1;3-oxazole 2 from AMNT (1) and the appropriate carboxylic acid (Rhodamin B) in the presence of pyridine (Scheme 1). This convenient method afford 1;3-oxazole derivative 2 directly from acid and AMNT (1); and avoids the prior step of preparation of acid chlorides. The DCC coupling method has broader applications. For example; 2hydroxy oxazoles can be prepared directly from hydroxyl acids.},
}

[Download]

%0 Conference Proceedings
%T A convenient one-pot method for the synthesis of highly functionalized 1,3-oxazole
%A A. Nikseresht
%A S. Parak
%A Bakavoli, Mehdi
%A J. Lari
%A H. Vahedi
%J 20th Iranian Seminar of Organic Chemistry
%D 2013

[Download]