13th Iranian Congress of Biochemistry and 5th International Congress of Biochemistry and Molecular Biology , 2013-04-16

Title : ( Evaluation of miR-338-3p expression in tumor and non-tumor cells of esophageal squamous cell carcinoma patients )

Authors: H. Mollaie , M. Shafiee , S. J. Moshtaghian , B. Memar , Moein Farshchian , S. J. Mowla , Maryam Moghaddam Matin ,

Citation: BibTeX | EndNote

microRNAs are a new-identified class of non-coding RNAs undergo miss-regulated expression in a lot of diseases such as cancer, in addition to their physiologic roles. Esophageal cancer is one of the most lethal cancers that its mortality: incidence ratio is about 91% and at the time of diagnosis, nearly 50% of patients have metastasis. Northeast of Iran has one of the highest incidence rates of esophageal cancer worldwide. Our aim in this study has been to evaluate miR-338-3p expression level in tumor cells of esophageal squamous cell carcinoma (ESCC) in comparison with non-tumor marginal area, to evaluate the suitability of this microRNA as a potential biomarker. After preparation of 37 FFPE clinical samples (tumor cells and non-tumor marginal area), extraction total RNA, cDNA synthesis and Real-time PCR amplification of miR-338-3p was performed. Statistical analysis indicates that the expression level of miR-338-3p in tumor cells is significantly (0.01) different from non-tumor marginal area. This result suggests that miR-338-3p may be potential biomarker for early diagnosis of ESCC.

Keywords

, microRNA, biomarker, esophageal cancer,
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@inproceedings{paperid:1035732,
author = {H. Mollaie and M. Shafiee and S. J. Moshtaghian and B. Memar and Farshchian, Moein and S. J. Mowla and Moghaddam Matin, Maryam},
title = {Evaluation of miR-338-3p expression in tumor and non-tumor cells of esophageal squamous cell carcinoma patients},
booktitle = {13th Iranian Congress of Biochemistry and 5th International Congress of Biochemistry and Molecular Biology},
year = {2013},
location = {یزد, IRAN},
keywords = {microRNA; biomarker; esophageal cancer; miR-338-3p},
}

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%0 Conference Proceedings
%T Evaluation of miR-338-3p expression in tumor and non-tumor cells of esophageal squamous cell carcinoma patients
%A H. Mollaie
%A M. Shafiee
%A S. J. Moshtaghian
%A B. Memar
%A Farshchian, Moein
%A S. J. Mowla
%A Moghaddam Matin, Maryam
%J 13th Iranian Congress of Biochemistry and 5th International Congress of Biochemistry and Molecular Biology
%D 2013

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