1,3,4-Thiadiazines represent the most widely studied class of compounds among the six theoretically possible thiadiazine isomers; they are of interest in a chemical sense because they are labile compounds which are capable of undergoing intramolecular rearrangements to give thiazole and pyrazole derivatives. Moreover, 1,3,4-thiadiazines exhibit a broad spectrum of biological activity1. In addition, 1,2,4-Triazoles and their derivatives play important role inmedicinal, agricultural and industrial fields [1–4]. In this study we described the synthesis of six novel Tetrazolo[5,1-b][1,3,4]Thiadiazines (5a–f) and (6a-f) wherein the biologically active 1,3,4-thiadiazine moiety is fused to a potent tetrazol ring across the 2,3-positions (Scheme 1).

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