In this research, magnetic nanoparticles were prepared from salt aqueous solutions with respective stoichiometry in an alkaline medium by co-precipitation method. The precipitated particles were used for the preparation of ferrofluid. Targeted drug delivery is an application of ferrofluid based on magnetic nanoparticles. Ferrofluid is biocompatible and therefore it is one of the most extensively used biomaterials for different application in medicine. Ferrofluid was discovered by Elmor in 1938. It is a colloidal mixture of magnetic particles that have 10-100 nm diameters in a liquid carrier. This liquid carrier contains a surfactant, which prevent the sticking of particles. Ferrofluid can be suspended in water or in an organic solvent. A typical ferrofluid contain 5% magnetic solids, 10% surfactant, and 85% carrier. Various nonmagnetic microcarries are successfully utilized for drug targeting but they show poor site specificity and are rapidly cleared off by RES (reticuloendothelial system) under normal circumstances. Ferrofluid carriers were developed to overcome two major problems encountered in drug targeting namely RES clearance and target site specificity. In this research, after preparation magnetic nanoparticles, samples were characterized by XRD and Fourier transform infrared spectroscopy (FTIR). Mean size of nanoparticles were about 8 nm and showed single-phase and cubic spinel structure.

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