Journal of Cell and Molecular Research, Volume (5), No (2), Year (2013-11) , Pages (54-59)

Title : ( Evaluation of relationship between HNF-1α and GLP-1R polymorphisms and type 2 diabetes in a population living in northeast of Iran )

Authors: Samaneh Sepahi , Razieh Jalal , , Ahmad Asoodeh , Jamshid Darvish ,

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The prevalence of type 2 diabetes mellitus (T2DM) is rising dramatically in the Middle East, especially in the Islamic Republic of Iran, but the genetic basis of type 2 diabetes in Iran is poorly understood. Polymorphisms of hepatocyte nuclear factor-1α (HNF-1α) and glucagon-like peptide-1 receptor (GLP-1R) genes showed association with type 2 diabetes in several ethnic groups. In this study, we evaluated whether these markers confer susceptibility to T2DM in a diabetic population living in Mashhad (northeast of Iran). Genotyping of Ala98Val (HNF-1α) and Thr149Met (GLP-1R) was done by the restriction fragment length polymorphism-PCR (RFLP-PCR) method in the following groups: 1) early-onset diabetes (age at onset ≤ 35 years); 2) late-onset diabetes (age at onset > 35 years); and 3) control. Our results showed that CT (Ala/Val) genotype of HNF-1α was higher in the early-onset type 2 diabetic group compared to the controls but difference was not significant. We did not find the GLP-1R Thr149Met mutation in all participants. The prevalence of the HNF-1α (Ala98Val) and (GLP-1R) Thr149Met mutations has not been previously reported in Iranian participants. We conclude that these mutations are not a common cause of T2DM in our studied population.

Keywords

, Type 2 diabetes; Hepatocyte nuclear factor, 1α; Glucagon, like peptide, 1 receptor;
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@article{paperid:1039033,
author = {Sepahi, Samaneh and Jalal, Razieh and , and Asoodeh, Ahmad and Darvish, Jamshid},
title = {Evaluation of relationship between HNF-1α and GLP-1R polymorphisms and type 2 diabetes in a population living in northeast of Iran},
journal = {Journal of Cell and Molecular Research},
year = {2013},
volume = {5},
number = {2},
month = {November},
issn = {2008-9147},
pages = {54--59},
numpages = {5},
keywords = {Type 2 diabetes; Hepatocyte nuclear factor-1α; Glucagon-like peptide-1 receptor; Polymorphism},
}

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%0 Journal Article
%T Evaluation of relationship between HNF-1α and GLP-1R polymorphisms and type 2 diabetes in a population living in northeast of Iran
%A Sepahi, Samaneh
%A Jalal, Razieh
%A ,
%A Asoodeh, Ahmad
%A Darvish, Jamshid
%J Journal of Cell and Molecular Research
%@ 2008-9147
%D 2013

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