High lipid soluble propofol recently produce rapid short term anesthesia and used as induction and maintenance drug in veterinary anesthesia. Pancreatitis is known as a side effect of propofol that causes hypertriglyceridemia. To evaluate propofol effect on pancrease, serum activity of pancreatic enzymes (Lipase and Amylase) was measured in a propofol total intravenous anesthesia. Six clinical healthy dogs (weighed 19.33 ± 7.44 kg) were selected. Anesthesia induced by 8 mg/kg from a 1% propofol solution and maintained by 0.3 mg/kg/min continuous infusion of propofol. The main criteria of anesthesia was lateral recumbency of the animals during study, however Heart Rate, Pulse oximetry, Respiratory rate and temperature were measured during anesthesia in order to monitor anesthesia status. A control serum sample was taken 24 hours before anesthesia and serial samples were taken on immediately before anesthesia, minutes 2, 10, 30 and 60 during anesthesia and hours 2, 6, 12, 24, 48 and 72 after anesthesia. Induction of Anesthesia was smooth and eventless with the calculated doses but totally 4.45 mg/kg/min of propofol was used for maintenance of anesthesia that was higher than calculated doses. Serum activity of pancreatic enzymes was measured by spectrophotometry method and an autoanalyzer (Biotecnica targa 3000, Italy). Data was analyzed using two way ANOVA and p values of 0.05 and less considered as significant. No significant changes recorded in serum lipase and amylase activity in comparison to zero time. Based on these results, pancreatitis cannot be considered as a cause of hypertriglyceridemia in propofol administration.

Keywords