High lipid soluble propofol recently produce rapid short term anesthesia and used as induction and maintenance drug in veterinary anesthesia. Common side effects of propofol include hypotension and lipid profile change (hyper cholestrolemia and hyper triglyceridemia). There is no study about serum lipid profile changes following clinical propofol anesthesia in dogs. Serum level of Cholesterol, Triglyceride, HDL, LDL and Glucose was measured in a propofol total intravenous anesthesia. Six clinical healthy dogs (weighed 19.33 ± 7.44 kg) were selected. Anesthesia induced by 8 mg/kg from a 1% propofol solution and maintained by 0.3 mg/kg/min continuous infusion of propofol. Heart Rate, Pulse oximetry, Respiratory rate and temperature were measured during anesthesia in order to monitor anesthesia status. A control serum sample was taken 24 hours before anesthesia and serial samples were taken on immediately before anesthesia, minutes 2, 10, 30 and 60 during anesthesia and hours 2, 6, 12, 24, 48 and 72 after anesthesia. Data was analyzed using two way ANOVA and p values of 0.05 and less considered as significant. Triglyceride level (246.16±87.96), cholesterol (315.5 ± 120.39), LDL (140.66 ± 94.23) increased significantly in comparison to zero time. No significant changes recorded in serum HDL level.

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