Title : ( Bioinformatics identification, cloning and partial purification of antigenic regions of Clostridium novyi alpha toxin for immunization )
Authors: Fathi Nahafi M , Najme Gord Noshahri , Ali Makhdoumi , Shaban M ,
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Abstract
Clostridium novyi alpha toxin, which increases vascular permeability and causes cell rounding in cell culture, has around 200 kDa molecular weight, since a small fragment of an antigen can induce an immune response against whole antigen, cloning and production of the regions with high antigenicity has opend new possibilities for immunity against lethal toxin. A critical requirement of this strategy is the identification and selection of antigenic regions of the toxin. In this study, we describe a combination of bioinformatics, molecular biology and purification methods for the production of protein fragments expected for high antigenicity.
Keywords
, Bioinformatics antigenic regions, recombinat vaccine, Clostridium novyi
@inproceedings{paperid:1041469,
author = {Fathi Nahafi M and Gord Noshahri, Najme and Makhdoumi, Ali and Shaban M},
title = {Bioinformatics identification, cloning and partial purification of antigenic regions of Clostridium novyi alpha toxin for immunization},
booktitle = {12th International Congress of Immunology & Allergy of Iran},
year = {2014},
location = {تهران, IRAN},
keywords = {Bioinformatics antigenic regions; recombinat vaccine; Clostridium novyi},
}
%0 Conference Proceedings
%T Bioinformatics identification, cloning and partial purification of antigenic regions of Clostridium novyi alpha toxin for immunization
%A Fathi Nahafi M
%A Gord Noshahri, Najme
%A Makhdoumi, Ali
%A Shaban M
%J 12th International Congress of Immunology & Allergy of Iran
%D 2014
