Background and Aim: Pain is a frequent unpleasant sense in the life. Because of pain remedies side effects, more research for pain killers is required. Ferula szowitziana in traditional medicine mentioned as analgesic. Due to its monoterpenes its antinociceptive effect is expected also. In this study, its effect on chemical pain sensation was investigated. Methods: Hydroalcoholic extract of areal part of Ferula szowitziana was acquired. The extract solved in saline, ethanol and tween 80 (8:1:1). Male Wistar rats (200-250g) were used in five groups including control, sham (intraperitonealy or i.p. injection of solvent) and extract in three dose groups (50-100-200 mg/kg, i.p.). Formalin test is used for chemical pain assessment. Results: Extract caused antinociceptive effect both in the first and second phases of formalin test (one way ANOVA, n=7, p<0.01, p<0.05 respectively) in a dose dependence manner, especially in the first phase. Conclusion: It seems that the analgesic effect of Ferula is due to its monoterpenes such as α pinene, β pinene, limonene, caryophyllene and their various influences on peripheral and central nervous system which needs more investigation.

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