Title : ( Tendon Injury Healing with Fibroblast and Static Magnetic Field in Rabbit Model: Biomechanical and Histopathological Evaluation )
Authors: Setareh Ghasemi , Amin Bigham-Sadegh , Iraj Karimi , pezhman Mirshokraei , Ahmad Yousefi , Nazari Hasan ,Access to full-text not allowed by authors
Abstract
Objective-Tendons are highly subjected to injury. Fibroblast is one of the cells used in tendon healing; however, there’s no proved and reported result in regard to their use in tendon healing. In addition, there are some studies done on the effect of magnetic fields on tendon healing but the results are antithesis. The aim of this study is to evaluate the effect of simultaneous application of fibroblast and magnetic field on tendon healing in rabbit model. Design- Experimental study Animals- Nine healthy, adult New Zealand White rabbits Procedures- Both legs of rabbits were divided into 6 groups named empty, magnet, culture substance, culture substance-magnet, fibroblast, and fibroblast-magnet. After skin incision, superficial flexor tendon was exposed and cut transversely and then sutured with nylon 2/0 suture and Bunnel-Mayer stitch pattern. In three rabbits, 0.5 cc culture substance and in three others, 0.5 cc culture substance and fibroblast were injected in the incision area. Then all injuries were dressed up and in all rabbits, a piece of magnet was placed in the surrounding bandage of left leg for 7 days. After 3 months, rabbits were euthanized, tendons were extracted and biomechanical tests and histopathological tests were performed. Results- Only one of the biomechanical features (Ultimate Strength) showed a statistically significant difference (P<0.05) which in fibroblast-magnet group was better than other groups. Also, in histopathological evaluation fibroblast-magnet group showed better result in comparison with others. Conclusion and Clinical Relevance- In conclusion, simultaneous use of fibroblast cells and magnetic field has a positive effect on tendon healing,
Keywords
, Tendon healing, Biomechanics, Fibroblast, Static magnet@inproceedings{paperid:1045773,
author = {Setareh Ghasemi and Amin Bigham-Sadegh and Iraj Karimi and Mirshokraei, Pezhman and Ahmad Yousefi and Nazari Hasan},
title = {Tendon Injury Healing with Fibroblast and Static Magnetic Field in Rabbit Model: Biomechanical and Histopathological Evaluation},
booktitle = {4th international symposium of veterinary surgery (ISVS2014},
year = {2014},
location = {مشهد, IRAN},
keywords = {Tendon healing; Biomechanics; Fibroblast; Static magnet},
}
%0 Conference Proceedings
%T Tendon Injury Healing with Fibroblast and Static Magnetic Field in Rabbit Model: Biomechanical and Histopathological Evaluation
%A Setareh Ghasemi
%A Amin Bigham-Sadegh
%A Iraj Karimi
%A Mirshokraei, Pezhman
%A Ahmad Yousefi
%A Nazari Hasan
%J 4th international symposium of veterinary surgery (ISVS2014
%D 2014